Fertility preservation medicine: A new field in the care of young cancer survivors
Article first published online: 19 MAR 2009
Copyright © 2009 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 53, Issue 2, pages 267–273, August 2009
How to Cite
Oktay, K. and Oktem, O. (2009), Fertility preservation medicine: A new field in the care of young cancer survivors. Pediatr. Blood Cancer, 53: 267–273. doi: 10.1002/pbc.22003
- Issue published online: 9 JUN 2009
- Article first published online: 19 MAR 2009
- Manuscript Received: 6 FEB 2009
- Manuscript Accepted: 6 FEB 2009
- fertility preservation;
- menstrual function;
- ovarian cryopreservation;
- pregnancy after cancer;
Treatment modalities for numerous oncological and non-oncological conditions result in gonadal insufficiency and infertility. Furthermore, pelvic-abdominal radiation may result in uterine damage resulting in poor reproductive outcomes such as preterm birth, low birth weight, and spontaneous abortion in adult survivors of childhood cancers. In response to the recognition of the impact of cancer treatments on fertility, several fertility preservation techniques have been developed. In prepubertal children, fertility preservation options are usually limited to ovarian cryopreservation because of sexual immaturity, but oocyte freezing can be performed in adolescent children. Two prospective randomized studies showed no benefit of gonadal suppression with GnRH analogs to preserve gonadal function and thus this treatment should not be recommended. For adult survivors of childhood cancer who experienced reproductive failure, third party reproduction techniques are highly successful. Pediatr Blood Cancer 2009;53:267–273. © 2009 Wiley-Liss, Inc.