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Brief Report
Negative correlation between cerebrospinal fluid tau protein and cognitive functioning in children with acute lymphoblastic leukemia
Article first published online: 23 MAR 2009
DOI: 10.1002/pbc.22029
Copyright © 2009 Wiley-Liss, Inc.
Additional Information
How to Cite
Protas, P. T., Muszynska-Roslan, K., Holownia, A., Grabowska, A., Wielgat, P., Krawczuk-Rybak, M. and Braszko, J. J. (2009), Negative correlation between cerebrospinal fluid tau protein and cognitive functioning in children with acute lymphoblastic leukemia. Pediatric Blood & Cancer, 53: 105–108. doi: 10.1002/pbc.22029
Publication History
- Issue published online: 8 MAY 2009
- Article first published online: 23 MAR 2009
- Manuscript Accepted: 19 FEB 2009
- Manuscript Received: 15 SEP 2008
Funded by
- Medical University of Bialystok. Grant Number: 3-79945L
- Abstract
- Article
- References
- Cited By
Keywords:
- acute lymphoblastic leukemia;
- chemotherapy;
- cognitive functioning;
- neurotoxicity;
- tau protein
Abstract
The aim of the study was to assess whether cerebrospinal fluid tau protein is associated with cognitive changes in children with acute lymphoblastic leukemia (ALL). Examination of 38 ALL patients revealed a statistically significant increase in tau protein on treatment day 59 and at two points during consolidation phase. Cognitive functioning was examined in 19 patients at an average of 3.7 years after diagnosis. The level of tau at the initiation of maintenance therapy was negatively correlated with verbal abilities measured on an intellectual scale. The study suggests that standard ALL treatment may cause a decline in cognitive functioning. Pediatr Blood Cancer 2009;53:105–108. © 2009 Wiley-Liss, Inc.