Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7

Authors

  • Claudia M.J.M. Faaij MSc,

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • Annemieke J. Willemze PhD, MD,

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • Tom Révész PhD, MD,

    1. Department of Haematology/Oncology, Women's & Children's Hospital, Adelaide, South Australia, Australia
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  • Melania Balzarolo MSc,

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • Cornelis P. Tensen PhD,

    1. Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands
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  • Manja Hoogeboom BSc,

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • Maarten H. Vermeer PhD, MD,

    1. Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands
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  • Elisabeth van Wering PhD,

    1. The Dutch Childhood Oncology Group (DCOG), The Hague, the Netherlands
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  • Christian M. Zwaan PhD, MD,

    1. Paediatric Oncology/Haematology, Erasmus MC/Sophia Children's Hospital, Rotterdam, the Netherlands
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  • Gertjan J.L. Kaspers PhD, MD,

    1. Paediatric Oncology/Haematology, VU University Medical Centre, Amsterdam, the Netherlands
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  • Colin Story MSc,

    1. Department of Haematology/Oncology, Women's & Children's Hospital, Adelaide, South Australia, Australia
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  • Astrid G.S. van Halteren PhD,

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • Jaak M. Vossen PhD, MD,

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • R. Maarten Egeler PhD, MD,

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • Maarten J.D. van Tol PhD,

    Corresponding author
    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
    • Department of Paediatrics P3-P, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands.
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  • Nicola E. Annels PhD

    1. Division of Immunology, Haematology, Oncology, Bone Marrow Transplantation and Autoimmune Diseases, Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands
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  • Conflict of interest: Nothing to declare.

Abstract

Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. Pediatr Blood Cancer. 2010;55:344–348. © 2010 Wiley–Liss, Inc.

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