Conflict of interest: Nothing to declare.
Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7†
Version of Record online: 19 APR 2010
Copyright © 2010 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 55, Issue 2, pages 344–348, August 2010
How to Cite
Faaij, C. M.J.M., Willemze, A. J., Révész, T., Balzarolo, M., Tensen, C. P., Hoogeboom, M., Vermeer, M. H., van Wering, E., Zwaan, C. M., Kaspers, G. J.L., Story, C., van Halteren, A. G.S., Vossen, J. M., Egeler, R. M., van Tol, M. J.D. and Annels, N. E. (2010), Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7. Pediatr. Blood Cancer, 55: 344–348. doi: 10.1002/pbc.22500
- Issue online: 25 JUN 2010
- Version of Record online: 19 APR 2010
- Manuscript Accepted: 2 FEB 2010
- Manuscript Received: 20 NOV 2009
- The Histiocytosis Association of America
- Dutch Cancer Society. Grant Numbers: RUL 2001-2515, UL 2005-3657
- paediatric haematology/oncology
Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin. Pediatr Blood Cancer. 2010;55:344–348. © 2010 Wiley–Liss, Inc.