Conflict of interest: None
Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings†
Version of Record online: 31 MAR 2010
Copyright © 2010 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 55, Issue 1, pages 165–170, 15 July 2010
How to Cite
Ness, K. K., Li, C., Mitby, P. A., Radloff, G. A., Mertens, A. C., Davies, S. M., Hammond, S., Armstrong, G. T. and Robison, L. L. (2010), Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings. Pediatr. Blood Cancer, 55: 165–170. doi: 10.1002/pbc.22513
- Issue online: 13 MAY 2010
- Version of Record online: 31 MAR 2010
- Manuscript Accepted: 5 FEB 2010
- Manuscript Received: 14 NOV 2009
- National Cancer Institute, Bethesda, MD. Grant Number: CA 55727
- buccal mucosa;
- cohort study;
Analysis of biological samples in large cohort studies may provide insight into the mechanism of, and risk factors for, disease onset and progression.
This study describes the methods used to collect biological samples from a large multi-center cohort of childhood cancer survivors and siblings of childhood cancer survivors and evaluates the predictors of a positive response among these individuals.
Among survivors, female sex, white race/ethnicity, college graduation, never smoking, accessing the healthcare system in the past 2 years, and having a second malignant neoplasm were the strongest predictors of returning a sample. Among siblings, a similar demographic profile defined those likely to submit the requested sample.
To reduce selection bias and increase the value of these samples for future analysis, additional phone calls and reminders targeting non-responders are needed to improve response rates among those least likely to respond to a single mailed request. Pediatr Blood Cancer 2010;55:165–170. © 2010 Wiley-Liss, Inc.