Conflict of interest:
Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia†
Article first published online: 7 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 56, Issue 4, pages 658–660, April 2011
How to Cite
Kelly, C., Salvi, S., McClain, K. and Hayani, A. (2011), Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia. Pediatr. Blood Cancer, 56: 658–660. doi: 10.1002/pbc.22688
- Issue published online: 4 FEB 2011
- Article first published online: 7 DEC 2010
- Manuscript Accepted: 11 MAY 2010
- Manuscript Received: 30 DEC 2009
- acute lymphoblastic leukemia;
- bone marrow transplantation;
- hemophagocytic lymphohistiocytosis
We report a case of a child with precursor-B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL-directed therapy and HLH-directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post-transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658–660. © 2010 Wiley-Liss, Inc.