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Keywords:

  • carboplatin;
  • neurofibromatosis type 1;
  • plexiform neurofibroma

Abstract

Plexiform neurofibromas (PN) are a hallmark of neurofibromatosis type 1 (NF1). These large nerve tumors can be disfiguring and surgery is the only known standard therapy. Surgical intervention may be suboptimal due to the diffuse nature of PN. Here, we present a case in which we describe the use of high-dose carboplatin to treat the patient's testicular seminoma which resulted in the decrease in size of a PN in a patient with NF1. Pediatr Blood Cancer 2011;56:488–490. © 2010 Wiley-Liss, Inc.