Conflict of interest: The authors have no conflicts of interest to disclose.
Tumor-initiating cells and tumor vascularization†
Article first published online: 8 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 56, Issue 3, pages 335–340, March 2011
How to Cite
Zhang, L.-Z., Zhang, C.-Q., Yan, Z.-Y., Yang, Q.-C., Jiang, Y. and Zeng, B.-F. (2011), Tumor-initiating cells and tumor vascularization. Pediatr. Blood Cancer, 56: 335–340. doi: 10.1002/pbc.22886
- Issue published online: 10 JAN 2011
- Article first published online: 8 NOV 2010
- Manuscript Accepted: 27 SEP 2010
- Manuscript Received: 25 JUN 2010
- National Natural Science Foundation of China. Grant Numbers: 30973017, 30772182
- cancer stem cells (CSCs);
- tumor-initiating cells (TICs);
- vascular niche;
Tumor-initiating cells (TICs) with stem-like cell properties initiate and sustain progressive growth, resulting in a heterogeneous tumor mass. The survival and growth of tumors rely on the development of a vasculature to provide nutrients and oxygen. Crosstalk between TICs and vascularization may be one of the central players in the initiation, long-term maintenance, and progression of tumors. This review surveys current evidence concerning the crosstalk that occurs in tumor/stromal interactions, including genetic change, vascular niche, hypoxia, and dormancy of tumors. A better understanding of this crosstalk might help provide the basis for developing more effective therapeutic drug targets. Pediatr Blood Cancer 2011;56:335–340. © 2010 Wiley-Liss, Inc.