Conflict of Interest Statement: The authors have no conflicts of interest to disclose.
Death due to asthma in two adolescents with sickle cell disease†
Version of Record online: 28 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 56, Issue 3, pages 454–457, March 2011
How to Cite
Field, J. J., Horst, J., Strunk, R. C., White, F. V. and DeBaun, M. R. (2011), Death due to asthma in two adolescents with sickle cell disease. Pediatr. Blood Cancer, 56: 454–457. doi: 10.1002/pbc.22891
- Issue online: 10 JAN 2011
- Version of Record online: 28 NOV 2010
- Manuscript Accepted: 30 SEP 2010
- Manuscript Received: 28 JUL 2010
- sickle cell disease
In one prospective cohort study, a diagnosis of asthma was associated with an increased risk of mortality in individuals with sickle cell anemia or HbSS. However, a direct relationship between death and asthma exacerbation could not be documented. This report examines two adolescents with sickle cell disease (SCD) who died during worsening symptoms consistent with asthma. Autopsies in both individuals demonstrated pulmonary airway smooth muscle hyperplasia, basement membrane thickening, and eosinophilia, consistent with bronchial asthma. Individuals with SCD and asthma warrant ongoing education, treatment, and surveillance for life-threatening complications of asthma. Pediatr Blood Cancer 2011;56:454–457. © 2010 Wiley-Liss, Inc.