Conflict of interest: Nothing to declare.
TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma†
Article first published online: 9 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 57, Issue 1, pages 166–168, 15 July 2011
How to Cite
Massimino, M., Gandola, L., Pignoli, E., Seregni, E., Marchianò, A., Pecori, E., Catania, S. and Cefalo, G. (2011), TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma. Pediatr. Blood Cancer, 57: 166–168. doi: 10.1002/pbc.22915
- Issue published online: 9 MAY 2011
- Article first published online: 9 FEB 2011
- Manuscript Accepted: 15 OCT 2010
- Manuscript Received: 11 SEP 2010
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Hodgkin lymphoma radiotherapy;
- late effects;
Hypothyroidism remains a common late effect after irradiation of the neck/mediastinum for Hodgkins lymphoma (HL). We evaluated the protective effect of TSH suppression during neck/mediastinum irradiation. From 1998 to 2001, 14 consecutive euthyroid children were given, before and until the end of their radiotherapy on neck/mediastinum, L-thyroxine at TSH-suppressive doses. The 14 patients had adequate TSH suppression during irradiation in 8, inadequate in 6. The 8-year hypothyroidism-free-survival after irradiation was 75 ± 15% for the former group, 0% for the latter (P = 0.009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL. Pediatr Blood Cancer 2011;57:166–168. © 2011 Wiley-Liss, Inc.