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Disseminated intravascular coagulation due to IgM-mediated autoimmune hemolytic anemia


  • Conflict of interest: Nothing to declare.


Disseminated intravascular coagulation (DIC) due to red cell hemolysis has been previously attributed to transfusion-related hemolytic reactions, but not to autoimmune hemolytic anemia. We report a case of DIC in a child with complement-fixing IgM-mediated cold-agglutinin autoimmune hemolysis, which resulted in arterial thrombosis and gangrene of the upper and lower extremities. Pediatr Blood Cancer 2011; 57: 329–331. © 2011 Wiley-Liss, Inc.

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