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Lessons from the past: Opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies

Authors

  • Melissa M. Hudson MD,

    Corresponding author
    1. Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee
    2. University of Tennessee College of Medicine, Memphis, Tennessee
    3. Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee
    • St. Jude Children's Research Hospital, 332 North Lauderdale, Mailstop 735, Memphis, TN 38105.
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  • Joseph P. Neglia MD,

    1. Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota
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  • William G. Woods MD,

    1. Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Atlanta, Georgia
    2. Winship Cancer Institute, Emory University, Atlanta, GA
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  • John T. Sandlund MD,

    1. Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee
    2. University of Tennessee College of Medicine, Memphis, Tennessee
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  • Ching-Hon Pui MD,

    1. Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee
    2. University of Tennessee College of Medicine, Memphis, Tennessee
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  • Larry E. Kun MD,

    1. University of Tennessee College of Medicine, Memphis, Tennessee
    2. Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee
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  • Leslie L. Robison PhD,

    1. University of Tennessee College of Medicine, Memphis, Tennessee
    2. Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee
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  • Daniel M. Green MD

    1. Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee
    2. University of Tennessee College of Medicine, Memphis, Tennessee
    3. Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee
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  • Conflict of interest: Nothing to declare.

Abstract

Investigations of long-term outcomes have been instrumental in designing safer and more effective contemporary therapies for pediatric hematological malignancies. Despite the significant therapeutic changes that have occurred over the last five decades, therapy modifications largely represent refinements of treatment protocols using agents and modalities that have been available for more than 30 years. This review summarizes major trends in the evolution of treatment of pediatric hematological malignancies since 1960 to support the relevance of the study of late effects of historical therapeutic approaches to the design and evaluation of contemporary treatment protocols and the follow-up of present-day survivors. Pediatr Blood Cancer 2012; 58: 334–343. © 2011 Wiley Periodicals, Inc.

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