Conflict of interest: nothing to report.
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Research Article
Bevacizumab and irinotecan in children with recurrent or refractory brain tumors: Toxicity and efficacy trends†
Article first published online: 27 JAN 2012
DOI: 10.1002/pbc.24066
Copyright © 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Couec, M.-L., André, N., Thebaud, E., Minckes, O., Rialland, X., Corradini, N., Aerts, I., Bérard, P. M., Bourdeaut, F., Leblond, P. and on the behalf of the Comité Pharmacologie of the SFCE (2012), Bevacizumab and irinotecan in children with recurrent or refractory brain tumors: Toxicity and efficacy trends. Pediatr. Blood Cancer, 59: 34–38. doi: 10.1002/pbc.24066
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Publication History
- Issue published online: 17 MAY 2012
- Article first published online: 27 JAN 2012
- Manuscript Accepted: 5 DEC 2011
- Manuscript Received: 8 JUN 2011
- Abstract
- Article
- References
- Cited By
Keywords:
- bevacizumab;
- brain tumors;
- children;
- glioma
Abstract
Background
Bevacizumab, a monoclonal antibody targeting the vascular endothelial growth factor, has proven efficacy in some adult tumors; it is now proposed as a new therapeutic strategy for refractory or recurrent brain tumors in some children, either alone or combinated.
Procedure
We retrospectively analyzed 28 children who received bevacizumab on a compassionate basis for refractory or recurrent brain tumors between June 2007 and August 2010 in 7 French centers. Among them, 12 had high-grade gliomas, 7 low-grade gliomas, 4 ependymomas, 2 primitive neurectodermal tumors, 3 neuroglial tumors. The median age at start of bevacizumab was 11.0 years. Bevacizumab was administered at 5–10 mg/kg every 2 weeks, with concomitant chemotherapy for 27 patients.
Results
Bevacizumab was used in combination with irinotecan in 27 patients. Bevacizumab-related toxicity was mild. Toxicities reported were grade I–II hypertension (n = 4), proteinuria (n = 1), lymphopenia (n = 2), wound healing delay (n = 2). Whereas tumor reduction could be observed in 6:7 patients with low-grade gliomas, no efficacy could be documented in patients with high-grade glioma, nor PNET nor ependymoma.
Conclusion
Bevacizumab-related acute toxicity appears to be low in children, even in combination with irinotecan. Further prospective trials are required to confirm the hypothetical efficacy of bevacizumab and to assess the risk of long-term toxicity especially in the youngest children. Pediatr Blood Cancer 2012; 59: 34–38. © 2012 Wiley Periodicals, Inc.