Conflict of interest: Nothing to declare.
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Research Article
Late effects of total body irradiation and hematopoietic stem cell transplant in children under 3 years of age†‡
Article first published online: 27 JUL 2012
DOI: 10.1002/pbc.24252
Copyright © 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Levy, J. M. M., Tello, T., Giller, R., Wilkening, G., Quinones, R., Keating, A. K. and Liu, A. K. (2013), Late effects of total body irradiation and hematopoietic stem cell transplant in children under 3 years of age. Pediatr. Blood Cancer, 60: 700–704. doi: 10.1002/pbc.24252
- †
- ‡
Jean Mulcahy Levy and Tiffany Tello contributed equally to the preparation of this manuscript.
Publication History
- Issue published online: 13 FEB 2013
- Article first published online: 27 JUL 2012
- Manuscript Accepted: 13 JUN 2012
- Manuscript Received: 25 APR 2012
Funded by
- NIH/NICHD Child Health Research Career Development Award. Grant Number: K12 HD068372
- Abstract
- Article
- References
- Cited By
Keywords:
- ALL;
- BMT;
- late effects of cancer treatment;
- radiation therapy;
- total body irradiation
Abstract
Background
Total body irradiation (TBI) is an important component of hematopoietic stem cell transplant (SCT) for pediatric malignancies. With increasing survival rates, late effects of SCT become more important. Younger children may be at particular risk of late effects of radiation and SCT.
Methods
We retrospectively reviewed outcomes of children less than 3 years of age who received TBI as part of their preparative regimen for SCT at Children's Hospital Colorado. Clinical information including the date of last follow-up, most recent lab values, and physiologic tests were extracted from the medical record.
Results
Of 81 patients who underwent SCT, 19 received TBI and of those, 15 were long-term survivors available for review. Late effects occurring in greater than 50% of the children included abnormalities involving endocrine, metabolic, renal, cataracts, and neurocognitive systems. Other organs involved less commonly included liver, skeletal, and cardiac abnormalities. Solid tumors were a rare finding with only one patient developing a benign osteochondroma and no identified secondary malignancies.
Conclusions
TBI has been shown to be an important part of the preparative regimen for patients undergoing SCT. Our results, similar to other studies, suggest TBI in patients less than 3 years of age will likely result in multi-organ dysfunction including endocrine, metabolic, renal, eye, and neurocognitive abnormalities. A longitudinal study with standardized testing of these systems would further clarify the late effects concerns in this patient population. Pediatr Blood Cancer 2013; 60: 700–704. © 2012 Wiley Periodicals, Inc.