Conflict of interest: Nothing to declare.
Cytomegalovirus retinitis as an adverse immunological effect of pulses of vincristine and dexamethasone in maintenance therapy for childhood acute lymphoblastic leukemia†
Article first published online: 13 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 2, pages 329–331, February 2013
How to Cite
Moritake, H., Kamimura, S., Kojima, H., Shimonodan, H., Harada, M., Sugimoto, T., Nao-i, N. and Nunoi, H. (2013), Cytomegalovirus retinitis as an adverse immunological effect of pulses of vincristine and dexamethasone in maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr. Blood Cancer, 60: 329–331. doi: 10.1002/pbc.24298
- Issue published online: 14 DEC 2012
- Article first published online: 13 SEP 2012
- Manuscript Accepted: 2 AUG 2012
- Manuscript Received: 17 JUN 2012
- acute lymphoblastic leukemia;
- cytomegalovirus retinitis;
- maintenance therapy;
We describe a 5-year-old female with acute lymphoblastic leukemia (ALL) who suffered from cytomegalovirus (CMV) retinitis during maintenance therapy consisting of 6-mercaptopurine (6-MP) and methotrexate (MTX) with pulses of vincristine (VCR) and dexamethasone (DEX). Administration of anticytomegaloviral drugs led to a complete regression of active retinitis. Her low CD4 positive T cells and serum immunoglobulin G (IgG) recovered when maintenance therapy was resumed without VCR and DEX. The patient has been in complete remission (CR) for more than 5 months after completion of maintenance therapy without recurrence of CMV retinitis. Pediatr Blood Cancer 2013;60:329–331. © 2012 Wiley Periodicals, Inc.