Conflict of Interest: Nothing to report.
Early cisplatin induced ototoxicity profile may predict the need for hearing support in children with medulloblastoma†
Article first published online: 21 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 2, pages 287–292, February 2013
How to Cite
Lafay-Cousin, L., Purdy, E., Huang, A., Cushing, S. L., Papaioannou, V., Nettel-Aguirre, A. and Bouffet, E. (2013), Early cisplatin induced ototoxicity profile may predict the need for hearing support in children with medulloblastoma. Pediatr. Blood Cancer, 60: 287–292. doi: 10.1002/pbc.24307
- Issue published online: 14 DEC 2012
- Article first published online: 21 SEP 2012
- Manuscript Accepted: 8 AUG 2012
- Manuscript Received: 17 FEB 2012
- B.R.A.I.N child
Cisplatin (CDDP) ototoxicity is a significant side effect of the current treatment of medulloblastoma (MB). Cumulative dose of CDDP and age are recognized risk factors for hearing loss, but inter-individual susceptibility limits our ability to identify patients at risk for hearing loss. We describe the kinetics of early audiometric changes during therapy and identify profiles associated with a higher risk of needing hearing aids.
Serial audiometric evaluations were performed during and after completion of therapy in children with average risk (AR) and high-risk (HR) MB. Each audiogram was scored according to five grading systems. Variations of pure tone thresholds were analyzed at each frequency for each consecutive audiogram. CDDP dose modifications and hearing outcome were recorded.
A total of 258 audiograms from 35 patients (22 AR, 13 HR) were analyzed. Eighteen AR patients (81.3%) required dose reduction and the median cumulative dose of CDDP administered was 412.5 mg/m2 (150–600), corresponding to 68% of the intended dose. Three HR patients (23.0%) required dose reduction. At a median follow-up of 67 months (11–117), nine patients (25.7%) required hearing support: After two cycles of CDDP (150 mg/m2), the average hearing loss at 8,000 Hz was twice higher in the group that eventually required hearing support.
Early alteration of high-frequency thresholds may help identify individuals who will require hearing support. In the MB population, alternative strategies should be developed to limit the cumulative dose of CDDP to prevent significant ototoxicity. Pediatr Blood Cancer 2013;60:287–292. © 2012 Wiley Periodicals, Inc.