Conflict of Interest: Nothing to report.
Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression†
Article first published online: 19 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 2, pages 332–335, February 2013
How to Cite
Morales La Madrid, A., Nall, M. B., Ouyang, K., Minor, A., Raca, G., Kent, P., Miller, I., Schleiermacher, G., Janoueix-Lerosey, I. and Cohn, S. L. (2013), Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression. Pediatr. Blood Cancer, 60: 332–335. doi: 10.1002/pbc.24311
- Issue published online: 14 DEC 2012
- Article first published online: 19 SEP 2012
- Manuscript Accepted: 13 AUG 2012
- Manuscript Received: 12 JUL 2012
- Little Heroes Cancer Research Foundation
- Neuroblastoma Children's Cancer Society
- Super Jake Foundation
- Elise Anderson Neuroblastoma Research Fund
- Conquer Cancer Foundation
- St. Baldrick's Foundation
- localized neuroblastoma;
- metastatic relapse;
- segmental chromosomal alterations
Surgery alone is curative for most children with localized MYCN-non-amplified neuroblastoma. However, 10–15% will develop recurrent loco-regional disease, and very rarely, patients will relapse metastatically. Currently, it is not possible to predict which child with localized, MYCN-non-amplified neuroblastoma will develop disseminated disease. We report two children who presented with favorable biology, localized neuroblastoma and subsequently relapsed with metastatic disease after treatment with surgery. Whole-genome DNA copy number analyses performed on the diagnostic tumors identified 15 (case 1) and 8 (case 2) segmental chromosomal alterations. Further analysis of the prognostic value of whole-genome analysis in children with localized neuroblastoma is warranted. Pediatr Blood Cancer 2013;60:332–335. © 2012 Wiley Periodicals, Inc.