Conflict of interest: Nothing to declare.
Prophylactic administration of prothrombin complex concentrates for congenital prothrombin deficiency with a novel frameshift mutation, prothrombin saitama†
Article first published online: 14 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 3, pages 503–505, March 2013
How to Cite
Seki, M., Koh, K., Inoue, T., Tomita, Y., Kato, M., Shimizu, M., Morishita, E. and Hanada, R. (2013), Prophylactic administration of prothrombin complex concentrates for congenital prothrombin deficiency with a novel frameshift mutation, prothrombin saitama. Pediatr. Blood Cancer, 60: 503–505. doi: 10.1002/pbc.24387
- Issue published online: 15 JAN 2013
- Article first published online: 14 NOV 2012
- Manuscript Accepted: 9 OCT 2012
- Manuscript Received: 15 MAY 2012
Additional Supporting Information may be found in the online version of this article.
|pbc_24378_sm_SupplTab1.doc||33K||Supplementary Table S1|
|pbc_24378_sm_SupplTab2.docx||107K||Supplementary Table S2|
|pbc_24378_sm_SupplFigS1.tif||7775K||Supplementary Figure S1: Peer RCC was transfused on day 14 (36 ml/kg), 15 (10 ml/kg), 17 (10 ml/kg), and 21 (10 ml/kg). For the second intracranial hemorrhage on Day 72, RCC was transfused at 20 ml/kg. FFP was transfused on day 14 (10 ml/kg), 16 (10 ml/kg), and 17 (10 ml/kg) before the patient was diagnosed with FII deficiency. PCCs were administered as follows in FII units: Day 18 (40 U/kg), day 22 (80 U/kg), day 26 (80 U/kg), day 30 (100 U/kg), day 35 (50 U/kg), and day 40 (100 U/kg). On day 71 to 86, 100 U/kg was administered and after day 91, 130 U/kg was administered. We used head CTs to monitor his ICH. Head computed tomography was performed shown on the black arrow ().|
|pbc_24378_sm_SupplFigS2.tif||11211K||Supplementary Figure S2: Head computed tomography (CT) at the first intracranial hemorrhage in the left hemisphere (panel A). A widespread subdural hematoma was observed in the left temporal area and extended above and below the tentorium. A diffuse brain edema was observed and the density was entirely low. Head CT at the second intracranial hemorrhage in the right hemisphere (panel B). New subdural hematomas were observed in right temporal, occipital, and left parietal areas.|
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