Conflict of interest: Nothing to report.
Pharmacokinetic interaction between methotrexate and chloral hydrate†
Article first published online: 14 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 3, pages 518–520, March 2013
How to Cite
Dao, K., Ivanyuk, A., Buclin, T., Beck-Popovic, M. and Diezi, M. (2013), Pharmacokinetic interaction between methotrexate and chloral hydrate. Pediatr. Blood Cancer, 60: 518–520. doi: 10.1002/pbc.24393
- Issue published online: 15 JAN 2013
- Article first published online: 14 NOV 2012
- Manuscript Accepted: 15 OCT 2012
- Manuscript Received: 19 SEP 2012
- cell lymphoblastic leukemia–lymphoma;
- chloral hydrate;
- drug interactions;
We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high-dose chemotherapy when co-administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion. Pediatr Blood Cancer 2013; 60: 518–520. © 2012 Wiley Periodicals, Inc.