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Assembly of a cohort of children treated for acute myeloid leukemia at free-standing children's hospitals in the United States using an administrative database

Authors

  • Marko Kavcic MD,

    Corresponding author
    1. Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    • Division of Oncology, The Children's Hospital of Philadelphia, 4018 CTRB, 3501 Civic Center Blvd., Philadelphia, PA 19104.
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  • Brian T. Fisher DO, MSCE,

    1. Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    2. The Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    3. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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  • Kari Torp PhD,

    1. Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
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  • Yimei Li PhD,

    1. Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
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  • Yuan-Shung Huang MS,

    1. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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  • Alix E. Seif MD, MPH,

    1. Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    2. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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  • Marijana Vujkovic PhD,

    1. Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
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  • Richard Aplenc MD, PhD

    1. Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    2. The Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    3. Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    4. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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  • Conflict of interest: Nothing to declare.

Abstract

Pediatric Health Information System data were used to establish a multi-center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD-9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD-9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML. Pediatr Blood Cancer 2013; 60: 508–511. © 2012 Wiley Periodicals, Inc.

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