Conflict of Interest: Nothing to Report.
Massive splenic infarction in an adolescent with hemoglobin S-HPFH†
Article first published online: 31 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 7, pages E49–E51, July 2013
How to Cite
Whyte, D., Forget, B., Chui, D. H.K., Luo, H.-y. and Pashankar, F. (2013), Massive splenic infarction in an adolescent with hemoglobin S-HPFH. Pediatr. Blood Cancer, 60: E49–E51. doi: 10.1002/pbc.24444
- Issue published online: 22 MAY 2013
- Article first published online: 31 DEC 2012
- Manuscript Accepted: 21 NOV 2012
- Manuscript Received: 16 OCT 2012
- sickle cell disease;
- splenic infarction
Hemoglobin sickle-hereditary persistence of fetal hemoglobin (S-HPFH) is a condition in which there is compound heterozygosity for the Hb S mutation and the HPFH deletion. These patients have no anemia, little evidence of hemolysis and generally have a benign clinical course compared to other types of sickle cell anemia. We describe a 19-year-old male with HbS-HPFH who had no history of anemia or vaso-occlusive crisis, who presented with a massive splenic infarct. We conclude that patients with HbS-HPFH can occasionally present with severe complications and require a high level of clinical suspicion for complications when presenting to the hospital. Pediatr Blood Cancer 2013; 60: E49–E51. © 2012 Wiley Periodicals, Inc.