Magnesium homeostasis and hypomagnesemia in children with malignancy
Article first published online: 9 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 5, pages 734–740, May 2013
How to Cite
Kaplinsky, C. and Alon, U. S. (2013), Magnesium homeostasis and hypomagnesemia in children with malignancy. Pediatr. Blood Cancer, 60: 734–740. doi: 10.1002/pbc.24460
- Issue published online: 14 MAR 2013
- Article first published online: 9 JAN 2013
- Manuscript Accepted: 5 DEC 2012
- Manuscript Received: 16 OCT 2012
Hypomagnesemia is not uncommon among children with malignancies. It is especially seen in association with certain medications and can be further complicated by the presence of diarrhea and malnutrition. Severe hypomagnesemia may cause disturbances in the neuromuscular and cardiovascular systems. All patients with hypomagnesemia should be supplemented with the mineral, and urgent treatment is indicated when serum magnesium decreases below 1.0 mg/dl, a level under which symptoms may develop. This review addresses the essentials of magnesium physiology, and pathophysiology of hypomagnesemia, its etiologies, clinical manifestations and ways to treat it, with an emphasis on the child with hematologic/oncologic disorders. Pediatr Blood Cancer 2013; 60: 734–740. © 2013 Wiley Periodicals, Inc.