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Successful treatment of pediatric plasmacytoid dendritic cell tumors with a contemporary regimen for acute lymphoblastic leukemia

Authors

  • Karen D. Wright MD, MS,

    Corresponding author
    1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
    • Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mailstop 260, Memphis, TN 38105.
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  • Mihaela M. Onciu MD,

    1. Department of Pathology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • Elaine Coustan-Smith MS,

    1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • Dario Campana MD, PhD,

    1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • Susana C. Raimondi PhD,

    1. Department of Pathology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
    2. Cytogenetics Laboratory, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • Hiroto Inaba MD, PhD,

    1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • Raul Ribeiro MD,

    1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • Ching-Hon Pui MD,

    1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • John T. Sandlund MD

    1. Department of Oncology, St. Jude Children's Research Hospital, University of Tennessee College of Medicine, Memphis, Tennessee
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  • Conflict of interest: Nothing to declare.

Abstract

Dendritic cell leukemia (DCL) or hematodermic tumor is an uncommon subtype of acute leukemia. In contrast to adult cases, children tend to have a less aggressive course. The diagnosis of DCL should be considered when its characteristic morphologic features are present and leukemic cells co-express CD4 and CD56. Cases of DCL among pediatric patients have been reported to respond to therapeutic regimens for acute lymphoblastic leukemia, but details regarding the specifics of therapy are lacking. Pediatr Blood Cancer 2013; 60: E38–E41. © 2013 Wiley Periodicals, Inc.

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