Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Authors

  • Daniel M. Green MD,

    Corresponding author
    1. Departments of Epidemiology and Cancer Control, St. Jude Children's Research Hospital Memphis, Memphis, Tennessee
    • Departments of Epidemiology and Cancer Control, St. Jude Children's Research Hospital Memphis, 332 North Lauderdale Street, Mail Stop 735, Memphis, 38105-2794 TN.
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  • Larry E. Kun MD,

    1. Departments of Radiological Sciences, St. Jude Children's Research Hospital Memphis, Memphis, Tennessee
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  • Katherine K. Matthay MD,

    1. Department of Pediatrics, University of California San Francisco Medical Center-Parnassus, San Francisco, California
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  • Anna T. Meadows MD,

    1. Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
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  • William H. Meyer MD,

    1. Department of Pediatrics, Jimmy Everest Section of Pediatric Hematology/Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
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  • Paul A. Meyers MD,

    1. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, Newyork
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  • Sheri L. Spunt MD,

    1. Departments of Oncology, St. Jude Children's Research Hospital Memphis, Memphis, Tennessee
    2. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee
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  • Leslie L. Robison PhD,

    1. Departments of Radiological Sciences, St. Jude Children's Research Hospital Memphis, Memphis, Tennessee
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  • Melissa M. Hudson MD

    1. Departments of Epidemiology and Cancer Control, St. Jude Children's Research Hospital Memphis, Memphis, Tennessee
    2. Departments of Oncology, St. Jude Children's Research Hospital Memphis, Memphis, Tennessee
    3. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee
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  • Conflict of interest Statement: Drs. Green, Kun, Matthay, Meadows, Meyer, Meyers, Spunt, Robison, and Hudson affirm that they have no affiliations that they consider to be relevant and important with any organization that to any author's knowledge has a direct interest, particularly a financial interest, in the subject matter discussed. Such affiliations include, but are not limited to, employment by an industrial concern, ownership of stock, membership on a standing advisory council or committee, a seat on the board of directors, or being publicly associated with a company or its products.

Abstract

Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse-free survival and reduce long-term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects. Pediatr Blood Cancer 2013; 60: 1083–1094. © 2013 Wiley Periodicals, Inc.

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