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Keywords:

  • 24-hour collection;
  • homovanillic acid;
  • neuroblastoma;
  • single spot urine;
  • vanillylmandelic acid

Abstract

The determination of the two urinary catecholamine metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) is of crucial importance for the diagnosis and follow-up of neuroblastoma (NB). The standard practice for their measurement requires the use of 24-hour collections that are time consuming and difficult to obtain. In this article, we directly demonstrate that 24-hour collections and single spot urines are interchangeable for the determination of HVA and VMA expressed as ratio on creatinine concentration. This study can be useful for a faster management of NB at onset. Pediatr Blood Cancer 2013;60:E170–E172. © 2013 Wiley Periodicals, Inc.