Elisabetta Viscardi and Andrea Di Cataldo on behalf of Italian Association of Pediatric Hematology and Oncology (AIEOP).
Interchangeability between 24-hour collection and single spot urines for vanillylmandelic and homovanillic acid levels in the diagnosis of neuroblastoma
Article first published online: 29 JUN 2013
Copyright © 2013 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 12, pages E170–E172, December 2013
How to Cite
Cangemi, G., Barco, S., Reggiardo, G., Viscardi, E., Di Cataldo, A., Garaventa, A., Melioli, G. and Conte, M. (2013), Interchangeability between 24-hour collection and single spot urines for vanillylmandelic and homovanillic acid levels in the diagnosis of neuroblastoma. Pediatr. Blood Cancer, 60: E170–E172. doi: 10.1002/pbc.24671
- Issue published online: 8 OCT 2013
- Article first published online: 29 JUN 2013
- Manuscript Accepted: 5 JUN 2013
- Manuscript Received: 10 APR 2013
- Cinque per mille dell'IRPEF—Finanziamento della ricerca sanitaria
- Fondazione Italiana per la Lotta al Neuroblastoma
- 24-hour collection;
- homovanillic acid;
- single spot urine;
- vanillylmandelic acid
The determination of the two urinary catecholamine metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) is of crucial importance for the diagnosis and follow-up of neuroblastoma (NB). The standard practice for their measurement requires the use of 24-hour collections that are time consuming and difficult to obtain. In this article, we directly demonstrate that 24-hour collections and single spot urines are interchangeable for the determination of HVA and VMA expressed as ratio on creatinine concentration. This study can be useful for a faster management of NB at onset. Pediatr Blood Cancer 2013;60:E170–E172. © 2013 Wiley Periodicals, Inc.