Conflict of interest: Nothing to declare.
Evaluation of renal function after successful treatment for unilateral, non-syndromic wilms tumor
Article first published online: 19 AUG 2013
© 2013 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 60, Issue 12, pages 1929–1935, December 2013
How to Cite
Green, D. M. (2013), Evaluation of renal function after successful treatment for unilateral, non-syndromic wilms tumor. Pediatr. Blood Cancer, 60: 1929–1935. doi: 10.1002/pbc.24738
Dr. Green affirms that he has no affiliations that he considers to be relevant and important with any organization that to his knowledge has a direct interest, particularly a financial interest, in the subject matter discussed. Such affiliations include, but are not limited to, employment by an industrial concern, ownership of stock, membership on a standing advisory council or committee, a seat on the board of directors, or being publicly associated with a company or its products.
- Issue published online: 8 OCT 2013
- Article first published online: 19 AUG 2013
- Manuscript Accepted: 25 JUL 2013
- Manuscript Received: 18 JUN 2013
- United States Public Health Service. Grant Number: CA-21765
- St. Jude Children's Research Hospital by the American Lebanese Syrian Associated Charities (ALSAC)
- late effects of treatment;
- pediatric oncology;
- renal function;
- Wilms tumor
Impaired renal function may occur in experimental animals following surgical removal of most functioning renal tissue (“hyperfiltration injury”). Although end-stage renal disease is uncommon among long-term survivors of unilateral, non-syndromic Wilms tumor, concern has been expressed that there may be an increased risk of less serious, but progressive, renal function impairment among these individuals. The recent development of equations for estimating glomerular filtration rate (eGFR) has facilitated the study of renal function in Wilms tumor survivors. However, the estimating equations were developed to categorize individuals with chronic kidney disease and have significant limitations with regard to the accuracy of individual GFR estimates. These limitations must be considered when utilizing the estimating equations in cross-sectional or longitudinal evaluations of renal function in cohorts of patients who have been treated successfully for Wilms tumor or other childhood cancers. Pediatr Blood Cancer 2013;60:1929–1935. © 2013 Wiley Periodicals, Inc.