Conflict of interest: Nothing to declare.
Vitamin B12 deficiency: The great masquerader
Version of Record online: 21 SEP 2013
© 2013 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 61, Issue 4, pages 753–755, April 2014
How to Cite
Dobrozsi, S., Flood, V. H., Panepinto, J., Scott, J. P. and Brandow, A. (2014), Vitamin B12 deficiency: The great masquerader. Pediatr. Blood Cancer, 61: 753–755. doi: 10.1002/pbc.24784
Contributor's statement: Dr. Sarah Dobrozsi drafted the initial manuscript and all revisions. Drs. Veronica H. Flood, Julie Panepinto, and J. Paul Scott reviewed the manuscript, and approved the final manuscript as submitted. Dr. Amanda Brandow conceptualized the manuscript, reviewed and revised the manuscript, and approved the final manuscript as submitted.
- Issue online: 6 FEB 2014
- Version of Record online: 21 SEP 2013
- Manuscript Accepted: 26 AUG 2013
- Manuscript Received: 30 JUL 2013
- intrinsic factor;
- pernicious anemia;
- vitamin B12
Vitamin B12 deficiency is rare in children, with nonspecific symptoms including failure to thrive, vomiting, anorexia, and neurologic changes with or without hematologic disturbances. The neuropathy can be severe and irreversible. We report four cases of children with B12 deficiency secondary to adult type pernicious anemia, a presumed transport protein abnormality, and a metabolic defect. All demonstrated neurologic compromise that improved after initiation of B12 therapy. Hematologic manifestations may be preceded by constitutional, gastrointestinal, or neurologic changes, and must raise concern for B12 deficiency. Therapy should be initiated promptly in this setting to prevent irreversible neuropathy. Pediatr Blood Cancer 2014;61:753–755. © 2013 Wiley Periodicals, Inc.