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Fetal alcohol spectrum disorders and childhood cancer: A concise review of case reports and future research considerations

Authors

  • Larry Burd PhD,

    Corresponding author
    1. Department of Pediatrics, North Dakota Fetal Alcohol Syndrome Center, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota
    • Correspondence to: Larry Burd, Department of Pediatrics, North Dakota Fetal Alcohol Syndrome Center, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.

      E-mail: larry.burd@med.und.edu

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  • Leah Peterson,

    1. Department of Pediatrics, North Dakota Fetal Alcohol Syndrome Center, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota
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  • Nathan Kobrinsky MD

    1. Department of Pediatrics, North Dakota Fetal Alcohol Syndrome Center, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota
    2. Department of Pediatrics, University of North Dakota School of Medicine and Health Sciences, Roger Maris Cancer Center, Sanford Health Systems, Fargo, North Dakota
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  • Conflict of interest: Nothing to declare.

Abstract

We reviewed the published literature on the relationship between childhood cancer and fetal alcohol spectrum disorders (FASD). A Pub Med search identified 12 subjects with the co-occurrence of FASD and cancer. We included an additional case from the author's institution. Neuroblastomas comprised 6 of the 13 (46%) case reports, yet neuroblastomas comprise only about 10% of childhood cancers (z = 4.1; P < 0.001). Other than rhabdomyosarcoma, no other cancer was reported more than once. Few cases of childhood cancer associated with FASD were identified likely due to under ascertainment of FASD. Pediatr Blood Cancer 2014;61:768–770. © 2013 Wiley Periodicals, Inc.

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