• 1
    Rees J, Watt H, Jager HR, et al. Volumes and growth rates of untreated adult low-grade gliomas indicate risk of early malignant transformation. Eur J Radiol 2009; 72:5464.
  • 2
    Youland RS, Brown PD, Giannini C, et al. Adult low-grade glioma: 19-year experience at a single institution. Am J Clin Oncol 2013; 36:612619.
  • 3
    Johnson DR, Brown PD, Galanis E, et al. Pilocytic astrocytoma survival in adults: Analysis of the surveillance, epidemiology, and end results program of the National Cancer Institute. J Neurooncol 2012; 108:187193.
  • 4
    Gunny RS, Haywood RD, Phipps KP, et al. Spontaneous regression of residual low-grade cerebellar pilocytic astrocytomas in children. Pediatr Radiol 2005; 35:10861091.
  • 5
    Rozen WM, Joseph S, Lo PA. Spontaneous regression of low-grade gliomas in pediatric patients without neurofibromatosis. Pediatr Neurosurg 2008; 44:324328.
  • 6
    Perilongo G, Moras P, Carollo C, et al. Spontaneous partial regression of low-grade glioma in children with neurofibromatosis-1: A real possibility. J Child Neurol 1999; 14:352356.
  • 7
    Schmandt SM, Packer RJ, Vezina LG, et al. Spontaneous regression of low-grade astrocytomas in childhood. Pediatr Neurosurg 2000; 32:132136.
  • 8
    Broniscer A, Baker SJ, West AN, et al. Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol 2007; 25:682689.
  • 9
    Afra D, Osztie E, Sipos L, et al. Preoperative history and postoperative survival of supratentorial low-grade astrocytomas. Br J Neurosurg 1999; 13:299305.
  • 10
    Parsa CF, Givrad S. Juvenile pilocytic astrocytomas do not undergo spontaneous malignant transformation: Grounds for designation as hamartomas. Br J Ophthalmol 2008; 92:4046.
  • 11
    National Cancer Institute, Surveillance, Epidemiology and End Results (SEER) program SEER*Stat database:incidence: SEER 17 Regs research data + hurricane katrina impacted Louisiana cases, Nov 2010 Sub (1973–2008 varying): Linked to County Attributes, DCCPS, Surveillance Research Program, Cancer Statistics Branch. 2011.
  • 12
    Pepe MS, Mori M. Kaplan-Meier, marginal or conditional probability curves in summarizing competing risks failure time data? Stat Med 1993; 12:737751.
  • 13
    Rosthoj S, Andersen PK, Abildstrom SZ. SAS macros for estimation of the cumulative incidence functions based on a Cox regression model for competing risks survival data. Comput Methods Programs Biomed 2004; 74:6975.
  • 14
    Lebel C, Walker L, Leemans A, et al., Microstructural maturation of the human brain from childhood to adulthood. NeuroImage 2008; 40:10441055.
  • 15
    Ater JL, Zhou T, Holmes E, et al. Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: A report from the Children's Oncology Group. J Clin Oncol 2012; 30:26412647.
  • 16
    Gnekow AK, Falkenstein F, von Hornstein S, et al. Long-term follow-up of the multicenter, multidisciplinary treatment study HIT-LGG-1996 for low-grade glioma in children and adolescents of the German Speaking Society of Pediatric Oncology and Hematology. Neuro Oncol 2012; 14:12651284.
  • 17
    Keene DL, Johnston DL, Grimard L, et al. Vascular complications of cranial radiation. Childs Nerv Syst 2006; 22:547555.
  • 18
    Campen CJ, Kranick SM, Kasner SE, et al. Cranial irradiation increases risk of stroke in pediatric brain tumor survivors. Stroke 2012; 43:30353040.
  • 19
    Ellenberg L, Liu Q, Gioia G, et al. Neurocognitive status in long-term survivors of childhood CNS malignancies: A report from the Childhood Cancer Survivor Study. Neuropsychology 2009; 23:705717.
  • 20
    Armstrong GT. Long-term survivors of childhood central nervous system malignancies: The experience of the Childhood Cancer Survivor Study. Eur J Paediatr Neurol 2010; 14:298303.
  • 21
    Galloway TJ, Indelicato DJ, Amdur RJ, et al. Second tumors in pediatric patients treated with radiotherapy to the central nervous system. Am J Clin Oncol 2012; 35:279283.
  • 22
    Müller K, Gnekow A, Falkenstein F, et al. Radiotherapy in pediatric pilocytic astrocytomas. A subgroup analysis within the prospective multicenter study HIT-LGG 1996 by the German Society of Pediatric Oncology and Hematology (GPOH). Strahlenther Onkol 2013; 189:647655.
  • 23
    Juratli TA, Kirsch M, Robel K, et al. IDH mutations as an early and consistent marker in low-grade astrocytomas WHO grade II and their consecutive secondary high-grade gliomas. J Neurooncol 2012; 108:403410.
  • 24
    Kim YH, Nobusawa S, Mittelbronn M, et al. Molecular classification of low-grade diffuse gliomas. Am J Pathol 2010; 177:27082714.
  • 25
    MacConaill LE, Campbell CD, Kehoe SM, et al. Profiling critical cancer gene mutations in clinical tumor samples. PLoS ONE 2009; 4:e7887.
  • 26
    Lin A, Rodriguez FJ, Karajannis MA, et al. BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549: BRAF fusion variants. J Neuropathol Exp Neurol 2012; 71:6672.
  • 27
    Tian Y, Rich BE, Vena N, et al. Detection of KIAA 1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn 2011; 13:669677.
  • 28
    Zhang J, Wu G, Miller CP, et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet 2013; 45:602612.