Conflict of interest: Nothing to declare.
Immune-mediated mechanism for thrombocytopenia after Loxosceles spider bite
Article first published online: 4 FEB 2014
© 2014 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 61, Issue 8, pages 1466–1468, August 2014
How to Cite
Levin, C., Bonstein, L., Lauterbach, R., Mader, R., Rozemman, D. and Koren, A. (2014), Immune-mediated mechanism for thrombocytopenia after Loxosceles spider bite. Pediatr. Blood Cancer, 61: 1466–1468. doi: 10.1002/pbc.24959
- Issue published online: 10 JUN 2014
- Article first published online: 4 FEB 2014
- Manuscript Accepted: 3 JAN 2014
- Manuscript Received: 28 OCT 2013
- immune-mediated thrombocytopenia;
- spider bite
Loxoscelism, characterized by high fever, vomiting, malaise, a dermonecrotic lesion, and thrombocytopenia, was diagnosed in a 3-year-old female. Clinical laboratory and dermatological signs are described. Blood test showed a transient hypercoagulable state and the presence of IgG antibodies against platelets, suggesting an immune-mediated mechanism for platelet destruction, in addition to the direct toxic effect of the spider venom. The finding of platelet antibodies after a Loxosceles spider bite has not been previously reported. Pediatr Blood Cancer 2014; 61:1466–1468. © 2014 Wiley Periodicals, Inc.