Tuberculosis in pediatric oncology and bone marrow transplantation patients

Authors

  • Andrea T. Cruz MD, MPH,

    Corresponding author
    1. Department of Pediatrics, Sections of Infectious Diseases, Baylor College of Medicine, Houston, Texas
    2. Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas
    • Correspondence to: Andrea T. Cruz, 6621 Fannin Street, Suite A2210, Houston, TX 77030.

      E-mail: acruz@bcm.edu

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  • Gladstone Airewele MBBS, MPH,

    1. Department of Hematology/Oncology, Baylor College of Medicine, Houston, Texas
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  • Jeffrey R. Starke MD

    1. Department of Pediatrics, Sections of Infectious Diseases, Baylor College of Medicine, Houston, Texas
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  • Conflict of interest: Nothing to report.

Abstract

Five children with malignancies (3 hematologic, 1 medulloblastoma, 1 hepatoblastoma) and one bone marrow transplant patient were treated for tuberculosis over a 30-year period. Three had pulmonary disease, 3 disseminated tuberculosis, and 1 had scrofula. Four of five had positive tuberculin skin tests, cultures were positive in 5/6 children. One child died of disseminated TB after engraftment, and one child had hepatotoxicity likely related to tuberculosis therapy. All cases were potentially preventable had they been screened due to established risk factors of foreign birth (4/6) or parental foreign birth (2/6). All children should be screened for latent tuberculosis before chemotherapy. Pediatr Blood Cancer 2014; 61:1484–1485. © 2014 Wiley Periodicals, Inc.

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