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Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review

Authors

  • L.T. Warris MD,

    1. Department of Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
    2. Department of Pediatric Endocrinology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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  • M.M. van den Heuvel-Eibrink MD, PhD,

    Corresponding author
    1. Department of Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
    • Correspondence to: M.M. van den Heuvel-Eibrink, Erasmus MC-Sophia Children's Hospital, Dr. Molenwaterplein 60, PO Box 2060, Room Number Na-1623, Rotterdam 3000 CB, The Netherlands.

      E-mail: m.vandenheuvel@erasmusmc.nl

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  • M.A.H. den Hoed BSc,

    1. Department of Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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  • F.K. Aarsen MSc, PhD,

    1. Department of Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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  • R. Pieters MD, PhD,

    1. Department of Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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  • E.L.T. van den Akker MD, PhD

    1. Department of Pediatric Endocrinology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
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  • Conflict of interest: Nothing to declare.
  • Author contributions: L.T. Warris performed the literature search, analyzed the results and wrote the paper. M.M. van den Heuvel-Eibrink and E.L.T. van den Akker analyzed the results and revised the paper critically. M.A.H. den Hoed performed the literature search. F.K. Aarsen and R. Pieters revised the paper critically.

Abstract

Steroid-induced neuropsychological side effects impact quality of life in children with acute lymphoblastic leukemia. Dexamethasone induces more metabolic side effects than prednisone. To evaluate whether dexamethasone also leads to more neuropsychological side effects, we reviewed all available literature. Randomized controlled trials with neuropsychological function as the primary or secondary outcome did not show clinically meaningful differences between dexamethasone and prednisone on cognition, mood or behavior. Pediatr Blood Cancer 2014;61:1313–1318. © 2014 Wiley Periodicals, Inc.

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