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pbc25002-sm-0001-SuppData-S1.eps2014KFig. S1. Pre-diagnostic interval for the onset of symptoms as a function of percentage of patients diagnosed. A: Pre-diagnostic interval in weeks plotted as a function of the percentage of patients at initial diagnosis for all medulloblastoma's (n = 126). B: Subgroup specific pre-diagnostic interval in weeks plotted as a function of the percentage of patients at initial diagnosis by subgroup. WNT (n = 16), SHH (n = 31), Group 3 (n = 27), Group 4 (n = 52), P = 0.0001 (Kruskal–Wallis test).
pbc25002-sm-0001-SuppData-S2.eps1555KFig. S2. A: Linear regression of the pre-diagnostic interval as a function of age at diagnosis. The solid line represents the best-fit regression line and dashed lines represent 95% confidence intervals. B: Subgroup specific linear regression of the pre-diagnostic interval as a function of age at diagnosis. Significant P-values <0.05 in bold.
pbc25002-sm-0001-SuppData-S3.eps1689KFig. S3. Subgroup specific survival analysis. Survival stratified by median pre-diagnostic interval within each subgroup for (A) SHH, (B) Group 3, and (C) Group 4. Survival stratified by a pre-diagnostic interval above and below 12 weeks for (D) WNT, (E) Group 3, and (F) Group 4. No SHH cases had a pre-diagnostic c interval above 12 weeks.
pbc25002-sm-0001-SuppData-S1.doc29KTable SI. Median Duration of Symptoms by Subgroup Divided by Weeks
pbc25002-sm-0001-SuppData-S2.doc28KTable SII. Frequency of Presenting Symptoms by Subgroup in Children <3

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