Conflict of interest: Nothing to declare.
Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent
Version of Record online: 25 FEB 2014
© 2014 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 61, Issue 7, pages 1190–1194, July 2014
How to Cite
Ramaswamy, V., Remke, M., Shih, D., Wang, X., Northcott, P. A., Faria, C. C., Raybaud, C., Tabori, U., Hawkins, C., Rutka, J., Taylor, M. D. and Bouffet, E. (2014), Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent. Pediatr. Blood Cancer, 61: 1190–1194. doi: 10.1002/pbc.25002
- Issue online: 2 MAY 2014
- Version of Record online: 25 FEB 2014
- Manuscript Accepted: 28 JAN 2014
- Manuscript Received: 6 OCT 2013
- Canadian Institutes of Health Research Clinician Scientist Phase II Award
- Canadian Institutes of Health Research
- Garron Family Chair in Childhood Cancer Research, Hospital for Sick Children
- University of Toronto
- Pediatric Brain Tumor Foundation
- Alberta Innovates-Health Solutions Clinical Fellowship
- Mildred Scheel Cancer Foundation Fellowship
Additional supporting information may be found in the online version of this article at the publisher's web-site.
|pbc25002-sm-0001-SuppData-S1.eps||2014K||Fig. S1. Pre-diagnostic interval for the onset of symptoms as a function of percentage of patients diagnosed. A: Pre-diagnostic interval in weeks plotted as a function of the percentage of patients at initial diagnosis for all medulloblastoma's (n = 126). B: Subgroup specific pre-diagnostic interval in weeks plotted as a function of the percentage of patients at initial diagnosis by subgroup. WNT (n = 16), SHH (n = 31), Group 3 (n = 27), Group 4 (n = 52), P = 0.0001 (Kruskal–Wallis test).|
|pbc25002-sm-0001-SuppData-S2.eps||1555K||Fig. S2. A: Linear regression of the pre-diagnostic interval as a function of age at diagnosis. The solid line represents the best-fit regression line and dashed lines represent 95% confidence intervals. B: Subgroup specific linear regression of the pre-diagnostic interval as a function of age at diagnosis. Significant P-values <0.05 in bold.|
|pbc25002-sm-0001-SuppData-S3.eps||1689K||Fig. S3. Subgroup specific survival analysis. Survival stratified by median pre-diagnostic interval within each subgroup for (A) SHH, (B) Group 3, and (C) Group 4. Survival stratified by a pre-diagnostic interval above and below 12 weeks for (D) WNT, (E) Group 3, and (F) Group 4. No SHH cases had a pre-diagnostic c interval above 12 weeks.|
|pbc25002-sm-0001-SuppData-S1.doc||29K||Table SI. Median Duration of Symptoms by Subgroup Divided by Weeks|
|pbc25002-sm-0001-SuppData-S2.doc||28K||Table SII. Frequency of Presenting Symptoms by Subgroup in Children <3|
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