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Co-inheritance of mild hemophilia A and heterozygosity for type 2N von Willebrand disease: A diagnostic and therapeutic challenge

Authors

  • Holly Lindsay MD,

    Corresponding author
    1. Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas
    • Correspondence to: Holly Lindsay, Fellow in Pediatric Hematology and Oncology, Baylor College of Medicine, 1102 Bates, Ste 1030.20J, Houston, TX 77030.

      E-mail: hblindsa@txch.org

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  • Katie Bergstrom MS, CGC,

    1. Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas
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    • Certified Genetic Counselor.
  • Lakshmi Srivaths MD

    1. Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas
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    • Associate Professor.

  • Conflict of interest: Nothing to declare.

Abstract

Hemophilia A and von Willebrand disease are the two most common inherited bleeding disorders. Despite their frequency, however, there are very few reports of co-inheritance of the two disorders. We present the first report of a patient with mild hemophilia A and heterozygosity for type 2N von Willebrand disease (VWD). We discuss the patient's phenotype and highlight the diagnostic and therapeutic challenges caused by this co-inheritance. Pediatr Blood Cancer 2014; 61:1888–1890. © 2014 Wiley Periodicals, Inc.

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