Successful treatment of pediatric histiocytic sarcoma using abbreviated high-risk leukemia chemotherapy


  • Conflict of interest: Nothing to declare.


Histiocytic sarcoma (HS) is a malignant tumor composed of proliferating cells of histiocytic origin. True HS is exceedingly rare, particularly in pediatric patients. These tumors are frequently aggressive, and outcome for patients with HS has traditionally been poor. There is currently no consensus on the optimal management of these tumors, with the literature consisting largely of case reports and small case series utilizing a wide variety of therapies. We describe a case of HS in an 8-year-old female who was successfully treated with an abbreviated leukemia chemotherapy regimen. Pediatr Blood Cancer 2014; 61:1874–1876. © 2014 Wiley Periodicals, Inc.