Conflict of interest: Nothing to declare.
Development of a quality of life instrument for children with advanced cancer: The pediatric advanced care quality of life scale (PAC-QoL)
Article first published online: 19 JUN 2014
© 2014 Wiley Periodicals, Inc.
Pediatric Blood & Cancer
Volume 61, Issue 10, pages 1840–1845, October 2014
How to Cite
Cataudella, D., Morley, T. E., Nesin, A., Fernandez, C. V., Johnston, D. L., Sung, L. and Zelcer, S. (2014), Development of a quality of life instrument for children with advanced cancer: The pediatric advanced care quality of life scale (PAC-QoL). Pediatr. Blood Cancer, 61: 1840–1845. doi: 10.1002/pbc.25115
- Issue published online: 19 AUG 2014
- Article first published online: 19 JUN 2014
- Manuscript Accepted: 1 MAY 2014
- Manuscript Received: 8 AUG 2013
- Pediatric Oncology Group of Ontario
- Childhood Cancer Canada Foundation
- Canadian Institutes of Health Research
- quality of life
There is currently no published, validated measures available that comprehensively capture quality of life (QoL) symptoms for children with poor-prognosis malignancies. The pediatric advanced care-quality of life scale (PAC-QoL) has been developed to address this gap. The current paper describes the first two phases in the development of this measure.
The first two phases included: (1) construct and item generation, and (2) preliminary content validation. Domains of QoL relevant to this population were identified from the literature and items generated to capture each; items were then adapted to create versions sensitive to age/developmental differences. Two types of experts reviewed the draft PAC-QoL and rated items for relevance, understandability, and sensitivity of wording: bereaved parents (n = 8) and health care professionals (HCP; n = 7). Content validity was calculated using the index of content validity (CVI [Lynn. Nurs Res 1986;35:382–385]).
One hundred and forty-one candidate items congruent with the domains identified as relevant to children with advanced malignancies were generated, and four report versions with a 5-choice response scale created. Parent mean scores for importance, understandability, and sensitivity of wording ranged from 4.29 (SD = 0.52) to 4.66 (SD = 0.50). The CVI ranged from 95% to 100%. These steps resulted in reductions of the PAC-QoL to 57–65 items, as well as a modification of the response scale to a 4-choice option with new anchors.
The next phase of this study will be to conduct cognitive probing with the intended population to further modify and reduce candidate items prior to psychometric evaluation. Pediatr Blood Cancer 2014; 61:1840–1845. © 2014 Wiley Periodicals, Inc.