Characterisation of the Metabolism of Pogostone In Vitro and In Vivo Using Liquid Chromatography with Mass Spectrometry (pages 97–105)
Yucui Li, Ziren Su, Shuhai Lin, Chuwen Li, Ya Zhao, Xiang Gao, Yongquan Lai, Xiaoli Wu, Hanzhi Wu, Zongwei Cai and Xiaoping Lai
Article first published online: 26 NOV 2013 | DOI: 10.1002/pca.2471
The metabolic profile of pogostone in vitro and in vivo was studied by using LC -MS techniques. In total, three mono-hydroxylated, one di-hydroxylated, one mono-oxygenated, one di-oxygenated metabolite, one hydrolysis and one hydroxy conjugated metabolites were found. And hydroxylation was demonstrated to be a major metabolic pathway of pogostone.