Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester
Article first published online: 5 MAR 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Volume 27, Issue 5, pages 457–462, May 2007
How to Cite
Akgun, H., Basbug, M., Ozgun, M. T., Canoz, O., Tokat, F., Murat, N. and Ozturk, F. (2007), Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester. Prenat. Diagn., 27: 457–462. doi: 10.1002/pd.1710
- Issue published online: 28 APR 2007
- Article first published online: 5 MAR 2007
- Manuscript Accepted: 21 JAN 2007
- Manuscript Revised: 15 JAN 2007
- Manuscript Received: 29 NOV 2006
- fetal anomalies;
- prenatal ultrasound: fetal autopsy;
- prenatal diagnosis
The aim of the study was to compare the consistency of major/minor fetal anomalies detected by second trimester prenatal ultrasound examination with the findings in fetal autopsies following the termination of pregnancy (TOP) in the second trimester.
In a 4-year long prospective study, 107 second-trimester TOP was performed due to fetal malformation diagnosed by second trimester-ultrasound examination at a tertiary referral center. Ultrasound findings were compared with fetal autopsy findings.
Of the 107 cases with major fetal anomalies diagnosed by prenatal ultrasound, 49% had central nervous system anomalies, 23% had kidney and urinary tract anomalies, 11% had congenital heart disease. All of these major anomalies leading to TOP were confirmed by fetal autopsy (100% success rate in major anomalies). Overall success rate in prenatal ultrasound for major and minor anomalies was 77%. The percentage of additional minor anomalies detected in fetal autopsies was 20%. Three percent of the minor anomalies detected by prenatal ultrasonography could not be confirmed during autopsy. Chromosomal anomalies were detected in 9 (16%) out of 57 cases.
Evaluation of fetal autopsies following TOP enables diagnosis of pathologies undetected by prenatal ultrasound alone, leading to better preconceptional counseling for subsequent pregnancies. Copyright © 2007 John Wiley & Sons, Ltd.