Maternal serum free α- and free β-human chorionic gonadotrophin in pregnancies with insulin-dependent diabetes mellitus: Implications for screening for Down's syndrome
Article first published online: 22 NOV 2005
Copyright © 1994 John Wiley & Sons, Ltd.
Volume 14, Issue 9, pages 835–837, September 1994
How to Cite
Wald, N. J., Densem, J. W., Cheng, R. and Collishaw, S. (1994), Maternal serum free α- and free β-human chorionic gonadotrophin in pregnancies with insulin-dependent diabetes mellitus: Implications for screening for Down's syndrome. Prenat. Diagn., 14: 835–837. doi: 10.1002/pd.1970140911
- Issue published online: 22 NOV 2005
- Article first published online: 22 NOV 2005
- Manuscript Accepted: 4 APR 1994
- Manuscript Revised: 29 MAR 1994
- Manuscript Received: 22 NOV 1993
- α and β free sub-units of hCG;
- insulin-dependent diabetes mellitus;
- maternal serum screening;
- Down's syndrome
A study was performed to investigate the concentrations of the α and β free sub-units of human chorionic gonadotrophin (free α-hCG and free β-hCG) in maternal serum between 15 and 22 weeks of pregnancy in 126 pregnancies among 92 women with insulin-dependent diabetes mellitus (IDDM). Each IDDM pregnancy was matched with two control singleton pregnancies for gestational age (same completed week) and duration of sample storage (same calendar quarter). The median free α-hCG level in the IDDM pregnancies was 0·86 multiples of the median (MOM) for pregnancies without IDDM at the same gestational age (P<0·002) (95 per cent confidence interval 0·80–0·94). The corresponding free β-hCG level was 0·96 MOM (95 per cent confidence interval 0·85–1·09). These results enable free α-hCG values to be adjusted so that antenatal screening for Down's syndrome can be performed using this marker in IDDM pregnancies as well as in non-diabetic pregnancies.