Assessment and management of fetal agenesis of the corpus callosum
Article first published online: 14 DEC 2005
Copyright © 1995 John Wiley & Sons, Ltd.
Volume 15, Issue 4, pages 301–312, April 1995
How to Cite
Gupta, J. K. and Lilford, R. J. (1995), Assessment and management of fetal agenesis of the corpus callosum. Prenat. Diagn., 15: 301–312. doi: 10.1002/pd.1970150402
- Issue published online: 14 DEC 2005
- Article first published online: 14 DEC 2005
- Manuscript Accepted: 29 NOV 1994
- Manuscript Revised: 24 NOV 1994
- Manuscript Received: 12 AUG 1994
- prenatal diagnosis;
- agenesis of the corpus callosum;
- prenatal counselling
Prenatal counselling for fetal agenesis of the corpus callosum is difficult as the prognosis until now has been so uncertain. We have reviewed the current world English literature to provide the best probabilistic information for prospective parents. In total, there are 70 cases where the diagnosis was made prenatally. The diagnosis of apparently isolated agenesis of the corpus callosum (in the absence of other sonographically detectable anomalies) appears to carry an excellent prognosis, with an 85 per cent chance of a normal developmental outcome and a 15 per cent risk of handicap. Fetal karyotyping is recommended as there is a 1 in 10 risk of aneuploidy. If other anomalies are detected prenatally, the outcome is very poor. Termination of pregnancy is advised in these circumstances.