Comparison of microarray-based detection rates for cytogenetic abnormalities in prenatal and neonatal specimens
Article first published online: 22 JUL 2008
Copyright © 2008 John Wiley & Sons, Ltd.
Volume 28, Issue 9, pages 789–795, September 2008
How to Cite
Shaffer, L. G., Coppinger, J., Alliman, S., Torchia, B. A., Theisen, A., Ballif, B. C. and Bejjani, B. A. (2008), Comparison of microarray-based detection rates for cytogenetic abnormalities in prenatal and neonatal specimens. Prenat. Diagn., 28: 789–795. doi: 10.1002/pd.2053
- Issue published online: 26 AUG 2008
- Article first published online: 22 JUL 2008
- Manuscript Accepted: 29 MAY 2008
- Manuscript Revised: 12 MAY 2008
- Manuscript Received: 24 JAN 2008
- array CGH;
- chromosome abnormality;
- dysmorphic features;
- copy number variant
To compare the detection rate by microarray analysis for chromosome abnormalities in a prenatal population to that of a neonatal population referred for diagnostic testing.
Array comparative genomic hybridization (aCGH) analysis was performed for 151 prenatal cases and compared with the results from 1375 postnatal cases less than 3 months of age.
Two of 151 prenatal cases (1.3%) showed a clinically significant cytogenetic abnormality. In contrast, of the 1375 postnatal cases studied, 11.4% showed a cytogenetic abnormality by aCGH. Many of these (40%) were referred for aCGH because of dysmorphic features, a clinical indication unlikely to be identified in the prenatal population.
The chance of detecting a chromosome abnormality in a prenatal population that has already been screened by routine cytogenetics is ∼1.3%. However, given that many of the abnormal array results in the neonatal population were among those with dysmorphic features as the primary indication for testing, which are not easily identifiable by ultrasound, offering prenatal testing by aCGH to a wider population would likely result in a higher detection rate. Copyright © 2008 John Wiley & Sons, Ltd.