Post-natal investigations: management and prognosis for fetuses with CNS anomalies identified in utero excluding neurosurgical problems
Article first published online: 30 MAR 2009
Copyright © 2009 John Wiley & Sons, Ltd.
Special Issue: Fetal CNS abnormalities: Prenatal diagnosis, management and outcome
Volume 29, Issue 4, pages 442–449, April 2009
How to Cite
Mighell, A. S., Johnstone, E. D. and Levene, M. (2009), Post-natal investigations: management and prognosis for fetuses with CNS anomalies identified in utero excluding neurosurgical problems. Prenat. Diagn., 29: 442–449. doi: 10.1002/pd.2245
- Issue published online: 30 MAR 2009
- Article first published online: 30 MAR 2009
- Manuscript Revised: 30 JAN 2009
- Manuscript Accepted: 30 JAN 2009
- Manuscript Received: 3 JUL 2008
- neurodevelopmental outcome;
- cerebral malformations;
- magnetic resonance
The suspicion of an abnormality of the central nervous (CNS) system raises difficult questions for the clinician and the family and will inevitably lead to considerable anxiety. These questions include what it means for the child's future, whether it can be treated and whether it will happen again in subsequent pregnancies. For many disorders accurate prenatal diagnosis remains elusive, as even with fetal magnetic resonance imaging (MRI), early recognition and characterisation are simply not possible because of the immature state of brain development at that stage of pregnancy. The natural history of many prenatally diagnosed CNS disorders remains to be elucidated which means that an accurate prognosis cannot be given in all cases. We review the current state of knowledge regarding the investigation, management and prognosis of the most common and important CNS malformations. We also discuss the post-natal management of these conditions both in the neonate and subsequent pregnancies for the families. Copyright © 2009 John Wiley & Sons, Ltd.