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Original Paper

ADAM12s as a first-trimester screening marker of trisomy

  1. E. J. Wortelboer1,†,*,
  2. I. H. Linskens2,†,
  3. M. P. H. Koster3,
  4. P. Stoutenbeek1,
  5. H. Cuckle5,
  6. M. A. Blankenstein4,
  7. G. H. A. Visser1,
  8. J. M. G. van Vugt2,
  9. P. C. J. I. Schielen3

Article first published online: 18 JUN 2009

DOI: 10.1002/pd.2300

Issue

Prenatal Diagnosis

Prenatal Diagnosis

Volume 29, Issue 9, pages 866–869, September 2009

Additional Information

How to Cite

Wortelboer, E. J., Linskens, I. H., Koster, M. P. H., Stoutenbeek, P., Cuckle, H., Blankenstein, M. A., Visser, G. H. A., van Vugt, J. M. G. and Schielen, P. C. J. I. (2009), ADAM12s as a first-trimester screening marker of trisomy. Prenat. Diagn., 29: 866–869. doi: 10.1002/pd.2300

Author Information

  1. 1

    Department of Obstetrics and Gynecology, University Medical Centre Utrecht, Utrecht, The Netherlands

  2. 2

    Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands

  3. 3

    National Institute for Public Health and Environment, Bilthoven, The Netherlands

  4. 4

    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

  5. 5

    Department of Obstetrics and Gynecology, Medical College of Columbia University, New York, USA

  1. †

    EJW and IHL contributed equally.

*Department of Obstetrics and Gynecology, University Medical Centre Utrecht, Utrecht, The Netherlands.

  1. †

    EJW and IHL contributed equally.

Publication History

  1. Issue published online: 28 AUG 2009
  2. Article first published online: 18 JUN 2009
  3. Manuscript Accepted: 18 APR 2009
  4. Manuscript Revised: 10 APR 2009
  5. Manuscript Received: 19 JAN 2009

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Keywords:

  • first-trimester combined test;
  • trisomy 21;
  • trisomy 13;
  • trisomy 18;
  • ADAM12s

Abstract

Objective

To evaluate the potential of maternal serum A Disintegrin And Metalloprotease 12-S (ADAM12s) as an additional marker for the combined test in the Dutch first-trimester national Down syndrome (DS) screening program.

Methods

Serum samples were collected between 2004 and 2007 as part of the national program. A total of 218 singleton cases of trisomy 21 (DS), 62 trisomy 18 (Edwards syndrome) and 29 trisomy 13 (Patau syndrome) were identified. All cases were matched with controls for gestation, maternal weight and maternal age. The serum concentration of ADAM12s was determined ‘blind’ to outcome and expressed in multiples of the gestation-specific median for controls (MoM).

Results

The median ADAM12s was 1.00 MoM in controls and in the DS cases at 8, 9, 10, 11, 12, 13 weeks it was 0.45 (n = 3), 0.73 (22), 0.74 (53), 0.85 (37), 0.92 (71), 1.06 (32) MoM, respectively. The median for trisomy 18 was 0.85 MoM and for trisomy 13 0.63 MoM.

Conclusion

The ADAM12s MoM values were clearly reduced in early first-trimester for all trisomies. However, the screening performance for DS did not greatly improve adding ADAM12s. ADAM12s could be an additional biochemical marker for first-trimester screening for trisomies other than DS. Copyright © 2009 John Wiley & Sons, Ltd.

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