First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome
Article first published online: 12 NOV 2009
Copyright © 2009 John Wiley & Sons, Ltd.
Volume 29, Issue 13, pages 1256–1261, December 2009
How to Cite
Pihl, K., Larsen, T., Laursen, I., Krebs, L. and Christiansen, M. (2009), First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome. Prenat. Diagn., 29: 1256–1261. doi: 10.1002/pd.2408
- Issue published online: 1 DEC 2009
- Article first published online: 12 NOV 2009
- Manuscript Accepted: 3 OCT 2009
- Manuscript Revised: 1 OCT 2009
- Manuscript Received: 18 AUG 2009
- pregnancy-specific glycoprotein;
- first trimester;
- preterm delivery;
To establish the first trimester levels of pregnancy-specific beta-1-glycoprotein (SP1) in pregnancies with adverse outcome. Furthermore, to determine the screening performance for adverse outcome using SP1 alone and in combination with other first trimester markers including proMBP and PAPP-A.
A case-control study was conducted in a primary hospital setting. The SP1 concentration was measured in first trimester maternal serum in pregnancies with small-for-gestational age fetuses (SGA) (n = 150), spontaneous preterm delivery (n = 88), preeclampsia (n = 40) and in controls (n = 500). Concentrations were converted to multiples of the median (MoM) in controls and groups were compared using Mann–Whitney U-test. Logistic regression analysis was used to determine significant factors for predicting adverse pregnancy outcome. Screening performance was assessed using receiver operating characteristic (ROC) curves.
The SP1 MoM median was significantly reduced in cases with SGA (0.76 MoM, p < 0.0005) and spontaneous preterm delivery (0.77 MoM, p < 0.0005) whereas no alteration was found in cases with preeclampsia (0.94 MoM, p = 0.723). A significant correlation (r = 0.217) between log10(SP1 MoM) and the birth weight percentile was found in the SGA group. Screening performance was only slightly improved when SP1 was combined with PAPP-A or proMBP.
SP1 is a first trimester maternal serum marker of SGA and preterm delivery. Copyright © 2009 John Wiley & Sons, Ltd.