Posterior brain in fetuses with open spina bifida at 11 to 13 weeks
Article first published online: 28 DEC 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Special Issue: 1st Trimester Screening and Diagnosis
Volume 31, Issue 1, pages 103–106, January 2011
How to Cite
Lachmann, R., Chaoui, R., Moratalla, J., Picciarelli, G. and Nicolaides, K. H. (2011), Posterior brain in fetuses with open spina bifida at 11 to 13 weeks. Prenat. Diagn., 31: 103–106. doi: 10.1002/pd.2632
- Issue published online: 5 JAN 2011
- Article first published online: 28 DEC 2010
- Manuscript Revised: 18 AUG 2010
- Manuscript Accepted: 18 AUG 2010
- Manuscript Received: 22 JUL 2010
- Fetal Medicine Foundation. Grant Number: 1037116
- first-trimester screening;
- brain stem;
- spina bifida;
- neural tube defect;
- nuchal translucency
To measure the changes in the posterior fossa in first-trimester fetuses with open spina bifida (OSB).
The brain stem diameter and brain stem to occipital bone (BSOB) diameter were measured in stored images of the mid-sagittal view of the fetal face at 11+0 to 13+6 weeks from 30 fetuses with OSB and 1000 normal controls.
In the control group, the brain stem and BSOB diameter increased significantly with crown-rump length (CRL) and the brain stem to BSOB ratio decreased. In the spina bifida group, the brain stem diameter was above the 95th percentile of the control group in 29 (96.7%) cases, the BSOB diameter was below the 5th percentile in 26 (86.7%) and the brain stem to BSOB ratio was above the 95th percentile in all cases.
At 11 to 13 weeks the majority of fetuses with OSB have measurable abnormalities in the posterior brain. Copyright © 2010 John Wiley & Sons, Ltd.