Integrative data mining to identify novel candidate serum biomarkers for pre-eclampsia screening
Article first published online: 22 SEP 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Volume 31, Issue 12, pages 1153–1159, December 2011
How to Cite
Pennings, J. L. A., Kuc, S., Rodenburg, W., Koster, M. P. H., Schielen, P. C. J. I. and de Vries, A. (2011), Integrative data mining to identify novel candidate serum biomarkers for pre-eclampsia screening. Prenat. Diagn., 31: 1153–1159. doi: 10.1002/pd.2850
- Issue published online: 25 NOV 2011
- Article first published online: 22 SEP 2011
- Manuscript Accepted: 2 AUG 2011
- Manuscript Revised: 28 JUL 2011
- Manuscript Received: 9 MAY 2011
- first-trimester serum screening;
Pre-eclampsia (PE) is a serious complication that affects approximately 2% of pregnant women worldwide. At present, there is no sufficiently reliable test for early detection of PE in a screening setting that would allow timely intervention. To help future experimental identification of serum biomarkers for early onset PE, we applied a data mining approach to create a set of candidate biomarkers.
We started from the disease etiology, which involves impaired trophoblast invasion into the spiral arteries. On the basis of this, we used a three-stage filtering strategy consisting of selection of tissue-specific genes, textmining for further gene prioritization, and identifying blood-detectable markers.
This approach resulted in 38 candidate biomarkers. These include the best three first-trimester serum biomarkers for PE found to date LGALS13 (placental protein 13, PP13), PAPPA (pregnancy-associated plasma protein-A, PAPP-A), and PGF (placental growth factor, PlGF), as well as five proteins previously identified as biomarker after the first-trimester or disease onset. This substantiates the effectiveness of our approach and provides an important indication that the list will contain several new biomarkers for PE.
We anticipate this list can serve in prioritization of future experimental studies on serum biomarkers for early onset PE. Copyright © 2011 John Wiley & Sons, Ltd.