Funding sources: Part of this work was supported by an award from the Efficacy and Mechanism Evaluation (EME) programme* and is funded by the Medical Research Council (MRC) and managed by the National Institute for Health Research (NIHR) on behalf of the MRC-NIHR partnership. Lyn S. Chitty is partially funded by the Great Ormond Street Hospital Children's Charity and the NIHR Biomedical Research Centre at Great Ormond Street Hospital. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Confined placental mosaicism: implications for fetal chromosomal analysis using microarray comparative genomic hybridization
Article first published online: 14 NOV 2013
© 2013 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 34, Issue 1, pages 98–101, January 2014
How to Cite
Karampetsou, E., Morrogh, D., Ballard, T., Waters, J. J., Lench, N. and Chitty, L. S. (2014), Confined placental mosaicism: implications for fetal chromosomal analysis using microarray comparative genomic hybridization. Prenat. Diagn., 34: 98–101. doi: 10.1002/pd.4255
*The EME Programme is funded by the MRC and NIHR, with contributions from the CSO in Scotland and NISCHR in Wales and the HSC R&D Division, Public Health Agency in Northern Ireland. It is managed by the NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC) based at the University of Southampton.
Conflicts of interest: None declared
- Issue published online: 2 JAN 2014
- Article first published online: 14 NOV 2013
- Manuscript Accepted: 8 OCT 2013
- Manuscript Revised: 3 OCT 2013
- Manuscript Received: 29 JUL 2013
What's already known about this topic?
- Use of microarray for prenatal diagnosis increases the detection of pathogenic chromosomal rearrangements.
- CPM is a well-established phenomenon occurring in 1–2% of CVS.
What does this study add?
- CPM can occur for submicroscopic copy number changes detected by array CGH in DNA from uncultured CVS. In order to minimise the risk of false-positive results in these cases, detected copy number changes should be confirmed in a different source of material, such as cultured cells.