Controversies in prenatal diagnosis 3: should everyone undergoing invasive testing have a microarray?

Authors


  • Funding sources: None

  • Conflicts of interest: None declared

Abstract

What's already known about this topic?

  • Chromosomal microarrays (CMA) are routinely used in postnatal genetic diagnosis.
  • CMA is technically applicable in prenatal diagnosis.
  • Pros and cons of routine use are discussed as follows: technical aspects and design of array, yield, interpretation of copy number variants and variances of unknown significance (VOUS), quality control regimens.

What does this study add?

  • Pros and cons of routine use are discussed as follows: technical aspects and design of array, yield, interpretation of copy number variants and variances of unknown significance (VOUS), quality control regimens.

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