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What's already known about this topic?

  • Chromosomal microarrays (CMA) are routinely used in postnatal genetic diagnosis.
  • CMA is technically applicable in prenatal diagnosis.
  • Pros and cons of routine use are discussed as follows: technical aspects and design of array, yield, interpretation of copy number variants and variances of unknown significance (VOUS), quality control regimens.

What does this study add?

  • Pros and cons of routine use are discussed as follows: technical aspects and design of array, yield, interpretation of copy number variants and variances of unknown significance (VOUS), quality control regimens.