Funding sources: This work is partly supported by the National Basic Research Program of China (2012CB944600) and the Hong Kong Health and Medical Research Fund (08090401).
Recurrent structural malformations identified among Mowat–Wilson syndrome fetuses
Article first published online: 23 DEC 2013
© 2013 John Wiley & Sons, Ltd.
Volume 34, Issue 3, pages 296–298, March 2014
How to Cite
Zhou, Y., Huang, J., Cheng, Y. K. Y., Leung, T. Y., Pooh, R. K., Lo, F. M. and Choy, K. W. (2014), Recurrent structural malformations identified among Mowat–Wilson syndrome fetuses. Prenat. Diagn., 34: 296–298. doi: 10.1002/pd.4292
Conflicts of interest: None declared
- Issue published online: 3 MAR 2014
- Article first published online: 23 DEC 2013
- Accepted manuscript online: 3 DEC 2013 05:16PM EST
- Manuscript Revised: 25 NOV 2013
- Manuscript Accepted: 25 NOV 2013
- Manuscript Received: 27 AUG 2013
What's already known about this topic?
- Mowat–Wilson syndrome (MWS) (OMIM#235730) is a genetic disease caused by mutations or deletions of the ZEB2 gene and characterized by typical facial dysmorphism. It is rarely diagnosed prenatally.
What does this study add?
- We report and review the ultrasound features of MWS fetuses identified by array comparative genomic hybridization study.
- The MWS should be considered in fetuses with increased nuchal translucency, ACC, hypospadias, and congenital heart defect.
- The prevalence of MWS in Hong Kong is reported.