Funding sources: None
Fetal cardiac disease and fetal lung volume: an in utero MRI investigation
Article first published online: 20 JAN 2014
© 2013 John Wiley & Sons, Ltd.
Volume 34, Issue 3, pages 273–278, March 2014
How to Cite
Mlczoch, E., Schmidt, L., Schmid, M., Kasprian, G., Frantal, S., Berger-Kulemann, V., Prayer, D., Michel-Behnke, I. and Salzer-Muhar, U. (2014), Fetal cardiac disease and fetal lung volume: an in utero MRI investigation. Prenat. Diagn., 34: 273–278. doi: 10.1002/pd.4308
Conflicts of interest: None declared
- Issue published online: 3 MAR 2014
- Article first published online: 20 JAN 2014
- Accepted manuscript online: 23 DEC 2013 08:46AM EST
- Manuscript Accepted: 16 DEC 2013
- Manuscript Revised: 10 DEC 2013
- Manuscript Received: 28 AUG 2013
Magnetic resonance imaging (MRI) is a powerful, noninvasive tool to study fetal lung volumes after 18 weeks of gestation in vivo. In neonates with congenital heart disease (CHD), proper lung function is essential for postnatal survival. Antenatal detection of abnormal pulmonary development may help to optimize prenatal and perinatal management of at-risk fetuses. We aimed to investigate lung volumes in fetuses with prenatally diagnosed heart disease.
A cross-sectional, retrospective study of 105 consecutive singleton pregnancies with CHD and a control, non-CHD group (n = 115), that underwent fetal MRI was performed. The heart defects detected were divided into four groups. Lung volumes of fetuses with heart disease were compared with control, non-CHD fetuses. In addition, z-scores of lung volumes were calculated for the CHD group (normal range z-scores from −2–+2).
As a group, fetuses with CHD have significantly smaller lung volumes compared with control fetuses when corrected by gestational age (GA) (p = 0.049). Of the 105 CHD fetuses studied, 18 had lung volumes with a z-score < −2. Fetuses with different types of CHD showed similar lung volumes.
Our data indicate that postpartum pulmonary symptoms and outcome in neonates with congenital heart disease may be attributed to the cardiac disease itself and in part to smaller lung volumes. © 2013 John Wiley & Sons, Ltd.